Posts tagged HIV
HIV May Evolve into an Ineffective Virus
9 years ago
HIV, like most viruses, evolves continually and at a rapid pace. Its process of replication is through constant mutation, so HIV cells can generate thousands of mutations of themselves. Some mutations die off before they take control over the virus cells of a host body, and some mutations become a dominant factor in the local virus population. Mutations that help the cells survive the longest have the best chance of dominating, and although some believe this may make HIV a stronger virus over time, there is evidence now emerging that shows the possibility that HIV may evolve – eventually – into a weaker, more treatable, and possibly ineffective virus.
The research showing this new evidence comes out of Africa. Philip Goulder, from the University of Oxford, and his team of researchers looked at the HIV epidemics in Botswana and South Africa. The epidemic started in Botswana roughly ten years before it hit South Africa, so the researchers took blood samples from roughly 2,000 HIV positive women from these two countries to compare the DNA structures of the viruses in each population. HIV cells in infected Botswanan women had developed mutations which helped them evade the immune system. Although this sounds like a bad sign, the mutations – in helping the virus evade detection – crippled the virus in many ways. Mutations in the Botswanan women slightly slowed down the replication speed of the virus cells, causing a 10% decrease in replication time. This slight variation helped the women’s immune systems keep up with the virus for a few years longer, causing a longer period between initial infection and when the virus caused AIDS to develop (meaning the immune system had been compromised completely).
This mutation only occurred over 10 years between when Botswana had its HIV outbreak and when the HIV outbreak spread to South Africa, so in a relatively short amount of time (one decade), HIV naturally evolved into a weaker virus. Goulder, of the research team looking at these mutations, says, “HIV can generate any mutation in the book, on any day,” so he’s not surprised that big mutations like this could occur so quickly. This mutation changes the time that the virus causes AIDS in untreated infected individuals to go from roughly 10 years to 12.5 years, which could mean the difference of life and death for those awaiting treatment. These mutations are already showing researchers where to focus their attacks on the virus, possibly leading to the development of an effective HIV vaccine. And, with the virus already mutating in this fashion, HIV may evolve to the point where the virus never completely compromises the natural human immune system, and where the immune system alone could maintain and control the HIV virus indefinitely.
Prevent the Spread of HIV Infection
9 years ago
by ADMIN
in HIV Prevention
Prevent the Spread of HIV Infection: Nanofiber-Based Technology Could Help
Human Immunodeficiency Virus (HIV) is spread through direct contact with blood, semen, pre-seminal fluid, vaginal fluids, fecal matter, breast milk, and other heavy fluids that our bodies produce. This virus attacks the T lymphocytes, a type of white blood cell that is a part of your immune system and prevents infections and diseases. Without treatment to prevent the virus from replicating itself, these T Cells eventually will become depleted. It is estimated that more than one million people over the age of thirteen are living with HIV infection. Of this number, roughly two hundred thousand infected people are unaware that they are HIV positive. The current therapies that stop the virus from replicating and spreading through the bloodstream will also stop the negative effects of HIV. However, they do not completely rid the body of the virus and do not prevent the possibility of further infection from occurring. Fortunately, there are new treatments in development that could actually prevent the spread of HIV infection around the world.
Of these new forms of prevention being developed, a group of researchers based out of the University of Missouri-Kansas City School of Pharmacy are testing a novel nanofiber-based technology. The aim is to prevent the transmission of HIV through vaginal mucus membranes. This vaginal-based drug is applied to the area prior to sexual contact, and is designed to take effect upon the presence of semen enzymes. The drug inactivates and kills any present HIV cells in the enzymes—prior to exposure and penetration of vaginal fluids. This is the main cause of heterosexual HIV transmission, HIV infected semen enzymes penetrating into the vaginal fluids and infecting the host, and this technology has been shown to effectively prevent the spread of HIV infection in this matter. They are working on using this technology in male-to-male sexual contact as well, and preliminary research looks positive.
AIDS Linked to Lymphoma
10 years ago
AIDS Linked to Lymphoma: CNS Involvement Is Vital
There are a number of connections between diseases that are well-documented and studied. There are also different systems in the body that seem to bear a connection with different diseases. HIV and AIDS seem to have connections with other diseases and with certain networks in the body. For example, doctors are aware that many who present with HIV or AIDS have a greater risk of developing lymphoma. New research shows that not only is AIDS linked to lymphoma, but that the operation of the central nervous system (CNS) also plays a role. The CNS is apparently closely linked to the lymphomas experienced by those with HIV and AIDS. What does this finding mean for a prognosis?
Researchers found that when a person has AIDS, they are at greater risk for lymphoma with central nervous system involvement. As the name suggests, lymphomas normally attack the lymph nodes. The next most common site, however, is the central nervous system. It appears the prognosis is not much different for HIV patients that present with either of these lymphomas. The study, however, found that when treating for cancer, CNS relapse was nearly 3 times more likely to happen in a person with AIDS. Moreover, because this form of cancer is particularly aggressive, the survival rate tends to be low. The hope is that knowing this link exists will help physicians to earlier detect and more effectively treat the disease. (Most people are probably aware that all forms of cancer are easier to treat the earlier that they are diagnosed).
After close consideration of cases of AIDS linked to lymphoma, it was noted that the majority presented with end-stage cancer. This may indicate that during the original diagnosis the CNS involvement may have been overlooked and, therefore, left untreated. Armed with this new information, doctors expect to be able to identify the disease sooner. Researchers, too, are looking into how the CNS is involved. The hope, of course, is this will lead to better treatment options in the future.
HIV to Treat HIV
10 years ago
by ADMIN
in HIV Research
HIV To Treat HIV: HIV ‘Cut and Paste’
Researchers recently applied the idea of ‘cut and paste’ to something completely different than word processing on their computers: the treatment of HIV. Of course, most of us use ‘cut-and-paste’ on a regular basis, whether for emails, documents, or filling in information. Certainly, it is a function that comes in handy. However, this cutting-edge technique could mean really big changes on the HIV battlefield. What we are talking about is using HIV to treat HIV. Obviously, this is an exciting idea. But, how does this process work? Moreover, how will this be beneficial in HIV treatment?
Within our cells are proteins, which are used to perform a variety of tasks. One of these proteins acts like a pair of scissors. It cuts away at the genome, grabbing and separating bits of information. The cell can then use the information as needed. For scientists, these natural ‘scissors’ can be used to help patch up damaged cells. The damaged cells, specifically those infected with HIV, have genetic bits of information missing. In order to patch up these holes, the ‘scissors’ could cut out patches from the virus and then use this to patch up the damaged cells. In effect, parts of the HIV would be cut away to repair the damage done by the disease. This may sound far-fetched, but recent testing gives reason for optimism.
HIV has been studied for nearly three decades and it may seem ironic to use HIV to treat HIV. However, it is a promising point of attack in the fight against HIV and AIDS, especially as this therapy looks particularly sound in the area of strengthening the immune system. Assisting the body to not only resist attack—but also to fend it off in such a manner—would be a big step in the fight against HIV. Should the cut and paste method prove successful, there may be other infections that could also be treated or prevented using similar methods.
HPV is a Risk Factor for HIV
10 years ago
by ADMIN
in HIV and HPV
HPV is a Risk Factor HIV: Study Confirms
The most common Sexually Transmitted Disease (STD) in the United States today is human papillomavirus (HPV). How common is it? Most sexually active men and women will get some form of HPV in their life, with an average of about 79 million Americans carrying the virus each year. Fortunately, HPV is rarely life-threatening, and though it has been linked to some forms of cervical cancer, this too is uncommon. Moreover, precancerous signs can be treated. In view of this fact, many doctors refer to HPV as the “common cold” of STDs. Because HPV is so common in the United States, and around the world, doctors usually never screen women for it until they are over the age of thirty. Unfortunately, no known HPV screening process exists for men, which is unfortunate as a study has confirmed that HPV is a risk factor for HIV.
The study linking these two STDs was performed in Kenya, a country where both HIV and HPV is very common. Research indicated that those with HPV, for various reasons, were 300 percent more likely to contract HIV. More surprising was this statistic was found to be true for both women and men.
It is perhaps to be expected that the likelihood of cancer resulting from HPV infections increases with each new exposure. One of the startling findings from this research, however, is the odds of contracting HIV immediately increases with only one infection of HPV. Therefore, if you are sexually active, it is highly encouraged that you receive an HPV vaccination.
This is important for a few reasons. First of all, there is no vaccine for HIV. So, anything a person can do to reduce the risk of contracting HIV is well worth it. Second, although an HPV vaccination is not inexpensive, this is nothing compared to the cost of cancer treatment, or of the daily cocktail of antiretroviral treatments that are needed to counteract HIV.
Hopefully, now that we know that HPV is a risk factor for HIV, it will encourage people to get vaccinated for HPV. This is a simple step that you can take to protect yourself, not only from HPV, but from the potential of contracting both cervical cancer and HIV.
