Posts tagged eliminating viruses
Research Shows Why HIV Progresses Faster in Some
9 years ago
A study was performed to determine why HIV is able to evade the efforts of current HIV treatments and persist in the body. This study will lead to improved HIV prevention. Let’s look at a breakdown of the HIV genetic code and what researchers found which may eventually lead to better treatments.
Researchers understand the way HIV spreads within the body. In order for HIV to enter a host cell, there is a sort of viral envelope. This envelope contains two glycoprotein molecules that have been named gp41 and gp120. The gp120 molecule has been further studied and broken down into sections that have been labelled with either a C or a V and the numbers 1 through 5.
In turn, this genetic code tells the virus to use the R5 receptor to enter a CD4 immune cell. This entry point is the focus of most HIV drugs. However, in about half of patients the virus will avoid using the R5 entry point and switch to the X4 receptor. This change results in a worsening of the disease and difficulty treating HIV with currently available medications.
Previous research made it seem that the gp120’s V3 region was the part that was solely responsible for this change and progression in how the disease spreads within the body. While the V3 region does clearly play a role, a minute genetic change in the gp120’s C2 region also comes into play. This genetic change, though slight, could prove to be an important discovery for researchers.
Now, it is up to researchers to figure out how to put this knowledge to use in combating HIV’s ability to progress despite treatment. It is hoped that the additional knowledge as to how the disease changes which receptor it focuses on will result in finding ways to predict progression and find a way to develop better means for HIV prevention and treatment.
HIV Outbreaks Spur Calls for Lifting Needle Exchange Ban
9 years ago
The drug scene in this country is changing and not for the better. Injection drug users are on the rise, just not where most expected. What was once contained and limited to larger, populated areas is now spreading to the most rural backdrops. Due to this surge, HIV outbreaks have been sprouting in what some would have considered, unlikely regions. Take for example a small agricultural county in Indiana.
This small county, bordering Kentucky, averaged just a few cases of HIV per year in the past. In the first half of this year, however, 169 new cases were reported – a drastic change. To add to that, 80% of those infected with HIV have been infected with Hepatitis C as well.
Experts long feared that this shift in demographic would bring about these tragic consequences. Drug abuse is now common among rural, predominantly white areas. Another alarming statistic shows that the number of male and female abusers are about equal. Along with injecting drugs comes the increased risk of spreading HIV. While proven methods in the past have effectively faced these challenges, one such method has a federal funding ban on it. Needle exchange programs worked well in the past to ensure that those who used needles would not pass them on to other users. A filled prescription for a needle could be refilled once the used needle was returned. It is a simple concept, but it worked and worked well.
The issue at hand is that there is currently a ban on federal funding for these programs. Without funding, the programs cease to run. Anyone with needle prescriptions can simply toss or pass along the used item. It is precisely these actions that have health officials worried that more HIV outbreaks in small communities will be making headlines. The call now is for a lift on this ban in hopes of stemming the changing tide.
As for the small Indiana community, the state governor has allowed funds to go into the needle exchange program for that county. The rest of the state will not be receiving the same benefits. The funding for each county is conditional: that is, based on need.
HIV Vaccine? Antibodies from Pregnant, HIV Positive Mothers
9 years ago
Not every child of HIV positive mothers ends up with the disease. The reasons for this have been hotly debated since it is hoped that the mechanism could be duplicated as some form of HIV vaccine. At first, a certain antibody response was considered a possible way that the disease was held at bay. While this was later discounted as being incorrect, new data has researchers once again believing that this antibody response is, in fact, the answer they have been searching for all along.
Each year, about a quarter of a million babies are born with HIV, having been infected during pregnancy by HIV positive mothers. This number, however, is only a small fraction of the babies born to HIV positive mothers during a year. The fact that something prevents most babies from infection certainly caught the attention of researchers who are always on the lookout for an HIV vaccine that can prevent infection.
The Notable Antibody Response
When infants are not infected with HIV due to transmission, the common variable seems to be what is referred to as a V3 neutralizing antibody (due to the fact that it responds to the V3 loop on the HIV envelope). This antibody had been written off by researchers in the past because it does seem to be a strong enough response to prevent transmission. In fact, it has proved ineffective in certain lab tests. So why does it prevent transmission from mother to child?
Additional Factors for HIV Positive Mothers
It is believed one of the factors that makes this immune response more effective in warding off transmission from mother to child lies in the effectiveness of the mother’s antibodies because they can neutralize HIV infection. Obviously, testing will now continue to determine if experimental vaccines can be boosted by this V3 neutralizing antibody. While every child is not kept safe from transmission by this antibody response, researchers hope to use this as a jumping point, something they can use one day to increase the effectiveness of an HIV vaccine someday.
Lack of HIV Prevention Threatens to Increase
9 years ago
by ADMIN
in HIV Management
UNAIDS has released a report showing that the next five years are critical in slowing the spread of HIV. Now that major advances in treatment have been made, HIV prevention seems to be less of a topic. The stark fact is that treatment alone will not stop the spread of HIV. To halt the continuing spread of this condition, prevention efforts need to be revamped, especially when it comes to high-risk groups.
Treatment Costs on the Rise
One of the amazing things about modern HIV treatment is that most people who are infected with the disease can expect to live to the average lifespan. This fact, however, also makes prevention a necessity. With HIV positive individuals living longer and the infection rate growing in many countries, costs of providing treatment are skyrocketing for governments around the world. In fact, in several African nations it has been calculated that more than one-third of government spending on health must target HIV, and that this translates into as much as 2% of the gross domestic product of some nations.
A Reachable yet Difficult Goal
UNAIDS sees the next five years as an opportunity to strike a major blow against HIV. With the funds to provide treatment globally and greater prevention encouragement for at-risk individuals, the organization is seeking to eliminate transmission from mother to child by 2030. The difficulty is encouraging the haves to share with the have-nots since many of the nations facing such crises simply do not have the funds to enact the needed programs.
First World Problem: Complacency
HIV prevention is not just an issue in Africa. In advanced nations such as in Europe and North America, evidence reveals that among homosexual men, infection rates have started to rise. This negative shift is blamed on complacency due to treatment methods and their accessibility in these nations. Rather than on treatment, the focus needs to be on prevention if infection rates in countries such as the US are going to decrease as they should.
New Potential Route to a Cure for HIV/AIDS
9 years ago
by ADMIN
in HIV Management
So much of the early research in finding a cure for HIV pointed towards the virus’s ability to lie dormant in the immune system of a host’s body, and scientists started believing a cure for the virus was impossible. Many decided, with this idea, to only focus their research on stopping the replication process of the virus cells and maintaining a healthy state of those infected. Some, though, still try novel ways to eliminate this difficult virus, as it can stay undetectable for years and suddenly resurface and eradicate the infected person’s immune system. In fact, one group of researchers has made some wonderful discoveries about which cells in the body the virus hides, once again paving a potential route to a cure for HIV. Most have concluded that the cells HIV usually hides in are our CD4 cells – also known as helper T cells – and since these are integral for our immune system to do its job, there was little we could do to eliminate the virus from those cells and the body as a whole. Surprisingly, this group of researchers has found another type of cell in which the virus may hide, one that is much more vulnerable to medical treatment and manipulation.
The research was lead by the Yerkes National Primate Research Center, in Emory University, as it involved monkeys that were infected by Simian Immunodeficiency Virus (SIV), which is essentially a sister virus to HIV that affects primates. Researchers examined these primates before and after infection, and in some they removed the helper T cells that many believe is the main focus for HIV’s attack. When they were removed, the virus cells attacked immune system cells called macrophages, which naturally have a much shorter lifespan than helper T cells. This is significant because the three-day lifespan of the macrophages is much less than an average helper T cell, meaning it would be difficult for the HIV cells to lie dormant for their required few weeks (minimum) to continue their replication process. This possible route to a cure for HIV means that we can now think of different methods to eradicate HIV, and no longer be bound to only the antiretroviral medications currently used to keep it at bay.
