The Importance of “Safe Spaces” in HIV Testing and Prevention
8 years ago
by ADMIN
in HIV Management
How HIV Testing and Prevention Can Be Improved
Despite advances in the treatment of HIV, some find it challenging to continue treatment, or even seek HIV testing or treatment in the first place. More and more research points to certain social stigmas as a possible cause. Some such stigmas are gay or bisexual black men are at the highest risk of contracting HIV. While they make up a small percentage of the population, they have the highest percentage of new cases – nearly 75% in just a span of a couple years. Experts are not only concerned with proper treatment of the disease, but also the lack of prevention tactics. Areas called Safe Spaces have proven beneficial for individuals with HIV or those at the highest risk of contracting the virus.
What Is a Safe Space?
A Safe Space can be a physical location or one on the Internet. It’s a place where individuals who feel shunned by society, their families, religion, or other institutions can come together and feel welcomed. Studies continually show that when people feel connected to others and receive support, they fare better with their diagnosis and maintain treatment schedules. It is well documented that Safe Spaces become acceptable and common hangouts for those who are HIV positive.
Challenges Facing Safe Spaces
The main challenge with the safe spaces program is, of course, funding. Budget cuts are common, and Safe Spaces are often the first to go. It is hoped that further studies of the value of such programs will be acknowledged instead of underestimated. Current research is underway as to how such spaces might contribute to the prevention of HIV. Those who frequent the Safe Spaces, but do not test positive, can be given medication to help the body prevent a future infection. As long as the safe space is there, this preventative measure could help many from contracting HIV. Other studies are examining how Safe Spaces may help other health issues, such as Hepatitis C, that carry a stigma.
The sense of community provided by Safe Spaces allows individuals to feel secure and open to have HIV testing, prevention and treatment. Experts are convinced that these spaces will prove invaluable tools for reaching those who lack other options.
Why At-Risk Adults, 50 and Over, Should Request HIV Screening Tests
For many aging adults, certain exams and tests at the doctor’s is a given. Those exams, along with their healthcare providers who pay for them, understand that with age comes certain increased health risks. One area of concern, however, has seemed to skip over this generation of adults. In the world of HIV screening tests, many doctors and other healthcare professionals simply overlook those within the older adult range. In light of this oversight, in 2006, the CDC issued a statement recommending that adults aged 50-64 be screened for HIV.
Research prior to that date had shown that this portion of the population had some living with an infection but not knowing it. Hence, we saw this call to healthcare givers to make a habit of testing older adults for the virus. While the suggestion was heeded, the effort was not sustained. This has caused some concern.
In the years leading up to 2006, the numbers were not high as far as HIV testing for this age group was concerned. Within just a three-year period, the percentage dropped from over 5% to just under 4%, this all taking place prior to the CDC‘s exhortation. In hopes of increasing awareness for these adults and their health care providers, the recommendation for HIV testing to be considered routine for this age group went out in 2006. The numbers did pick up immediately after the suggestion by the CDC was made. However, percentages only increased by one or two points. The news that researchers found most alarming was that this increase was not sustained. The number of older adults tested dropped within a couple years to below the average before the recommendation. Risk factors, however, have remained constant for this age group.
Awareness of these facts will hopefully spark additional efforts to revisit what was recommended nearly a decade ago. Not only should doctors be aware and do what they can for HIV screening tests for these adults, but patients may need to self-advocate in this instance. While no one looks forward to the list of health issues faced as we age, HIV is a big one to have crossed off the list. So check with your doctor and ask about HIV risks and testing at your next visit.
New Drug Make Awaken Dormant HIV Cells for Complete Eradication
8 years ago
by ADMIN
in HIV Research
Current treatments for HIV infections have come a long way over the past decade. Still research continues to try and find a cure for this tenacious viral invasion. While antiretroviral therapies may control the infection, treatment does not eliminate it completely from the body. There are some cells that have been infected with HIV that remain dormant and undetected by the immune system. Should a patient cease treatment, these cells could reactivate. However, recent research teams have noted a new class of drug that may be the key to purging these dormant cells. That could mean an HIV cure.
Cells that contain the HIV gene are difficult to find because they are wrapped up in the DNA. Certain drugs that are used to unravel this gene to treat other conditions still have a tough time finding the virus. Also, it is not easy to wake the virus as many of these types of drugs have not been successful in doing so. Here is where the new drug comes in. Smac mimetics, as it is called, works by acting as an alarm. This alarm acts quickly and is effective at awakening latent HIV-infected cells. It can do this without the risk of also activating the immune system which, if drastic enough, could prove fatal. But, the awakening of these cells can lead to detection by the immune system and eradication. All of this is accomplished because the drug uses the so-called back-door of the cell when it enters. Thus, a complete purge of the virus from the host occurs. If used together with the gene unraveling drugs, it is believed that Smac mimetics will prove successful.
With so much new information and so many trials underway, sometimes promising results do not make it into therapy for quite a while. This brings us to the other benefit of Smac mimetics – it is already being used for clinical trials in cancer treatments. The trials already conducted have gone very well. So while HIV-1 specific testing and formulating needs to be done, it is possible to see the drug being used for HIV in a much more reasonable timeframe than if it was a new development for an HIV cure.
The Body’s Immune Cells Actually Cause HIV Patients to Develop AIDS
9 years ago
by ADMIN
in HIV Research
That AIDS is brought about through an HIV infection is not new knowledge. Results from a recent investigation on the process from HIV infection to AIDS, however, sheds light on the topic. Actually, the findings show that it is the body’s own cells that cause AIDS, rather than the virus directly. This new concept could change how to proceed with treatment and HIV cure.
The virus, upon entering the host, infects a healthy immune system cell (CD4 T cells). The cell in turn can infect other healthy cells. Therefore, infection is spread either from the free-floating HIV itself or via the infected cells. While this has been common knowledge for some time, it was unknown that the latter is much more destructive when it comes to disease progression. Not only is cell to cell transfer much more efficient and effective, but it can also be deadly.
Once a healthy immune cell has been infiltrated, HIV DNA fragments begin to accumulate within the cell. At first it goes undetected, but the cleaning up of these fragments becomes too much for the cell, and it is eventually detected. This overload signals the cell’s defense system. This, in turn, triggers a molecular response. The chain of events that follows is fatal, cell suicide, if you will. Once the enzyme caspase-1 is activated, what usually follows is cell death (pyroptosis). This preprogrammed response in immune cells is a type of self-defense. Cell to cell infection is so successful because mass cell ‘suicides’ are what can eventually lead to disease progression, a wiped out immune system, and AIDS.
Upon this discovery, a number of experiments were performed to confirm the findings. The results supported what had been uncovered. Scientists are sure that it is due to the efficiency in which the infection transfers from cell to cell that leads to mass cell death. In turn, treatment of HIV and preventative measures against AIDS may now focus on inhibiting cell to cell transfer rather than just on the unattached virus itself. Turning attention to CD4 T cells and coming up with solutions that will prevent infection transfers should assist in halting not just the spread of infection, but also disease progression into AIDS and thus promise of an HIV cure.
Increased HCV in HIV-Positive MSM
9 years ago
by ADMIN
in HIV Prevention
Disturbing increases in the number of Hepatitis C infections among certain groups have researchers scrambling to find an effective means of combating it. The virus that causes Hepatitis C (HCV) is blood borne, making injectable drug use a common way to contract the infection. The latest trend, though, is not among people who inject drugs. It is among men who have sex with men (MSM) and are HIV positive. Just why this is happening and how to curb the upward swing in HCV numbers is what researchers are looking into controlling HIV.
Of course, people who inject drugs are certainly at risk for infection, so for the studies that had been performed on this topic, only those who did not abuse injectable drugs were followed so as not to skew the results. Unfortunately, throughout the last decade or so, the number of HIV-infected MSM who have contracted HCV had steadily increased. The problem is that, in recent years, those numbers have increased at a more rapid pace than had been previously predicted.
One risk factor has to do with those who abuses non-injectable drugs. Such drugs as methamphetamine also increased the risk for HCV infection nearly 29 fold. During the studies, a number of participants had repeat HCV infections. These individuals are 20 times more likely to be re-infected. They would contract the virus, seek out treatment, but then contract the disease once again. Not surprising then, high-risk sex behavior and drug abuse saw the highest increases when it came to Hepatitis C.
Projected numbers are not promising for the future either. Currently, out of 1,000 HIV-positive MSM about 20 will present with a Hepatitis C infection over the course of one year. The number of new HCV infection cases is only going to increase. Many believe that this is in part due to lack of education and prevention programs. Just what needs to be taught and which types of programs would prove effective remains to be seen. Education about safe sex practices and drug abuse are being developed to target this growing population. Further study on the matter is underway for controlling HIV.
